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KMID : 0357520160390040549
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Journal of Radiological Science and Technology
2016 Volume.39 No. 4 p.549 ~ p.555
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Guideliness of the Parameters Using Integrated Test in Down Syndrome Risk Prediction
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Lee Jin-Won
Ko Seung-Jin
Kang Se-Sik
Kim Chang-Soo
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Abstract
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This study was an evaluation of the significance of each parameter through aimed at pregnant women subjected to screening test(integrated test) in predicting risk of Down syndrome. We retrospectively analysed the correlation of risk of Down's syndrome with Nuchal Translucency(NT) images measured by ultrasound, Pregnancy Associated Plasma Protein A(PAPP-A), alpha-fetoprotein(AFP), unconjugated estriol(uE3), human chorionic gonadotrophin(hCG) and Inhibin A by maternal serum. As a result, a significant correlation with NT, uE3, hCG, Inhibin A is revealed with Down's syndrome risk(P<.001). In ROC analysis, AUC of Inhibin A is analysed as the biggest predictor of Down's syndrome(0.859). And the criterion for cut-off was inhibin A 1.4 MoM(sensitivity 81.8%, specificity 75.9%). In conclusion, Inhibin A was the most useful in parameters to predict Down's syndrome in the integrated test. If we make up for the weakness based on the cut-off value of parameters they will be able to be used as an independent indicator in the risk of Down's syndrome screening.
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KEYWORD
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Down syndrome risk , Intergrated test , Inhibin A , Nuchal Translucency
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